Marcelo J. Otero

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Área de investigación: Mecánica estadística y sistemas complejos

• Modelado de enfermedades transmitidas por vectores
• Modelos estocásticos
• Quimioinformática
• Ciencia de datos aplicada a Drug Discovery

Intereses

Utilización de herramientas de estadística computacional y modelización estocástica en el análisis y modelado de sistemas en diferentes escalas:

• Escala molecular: implementación y desarrollo de nuevas estrategias de análisis y modelado de información química para el diseño de compuestos sintéticos con actividad biológica relevante. Trabajo en colaboración con Javier Ramirez, Victoria Richmond y Pau Arroyo Mañez (UMYMFOR, Departamento de Química Orgánica, FCEyN, UBA).

• Escala poblacional: desarrollo de modelos estocásticos aplicados a la descripción de la dinámica poblacional de vectores y algunas de las enfermedades que estos propagan, de manera tal de crear herramientas de orientación, prevención y control, con aplicación en salud humana, veterinaria y agrícola. Trabajo en colaboración con H. G. Solari (IFIBA-DF, FCEyN, UBA), M. Giménez Pecci (INTA-Córdoba) y M. Natiello (Lund University, Suecia).

Links:

https://www.researchgate.net/profile/Marcelo_Otero2

http://orcid.org/0000-0001-6963-4333

https://www.scopus.com/authid/detail.uri?authorId=7101927480

http://publicationslist.org/marcelo.otero

Publicaciones seleccionadas

ARTÍCULOS / ARTICLES

“Beyond Pseudo?natural Products: Sequential Ugi/Pictet?Spengler Reactions Leading to Steroidal Pyrazinoisoquinolines That Trigger Caspase?Independent Death in HepG2 Cells”. Alonso, F., Galilea, A., Mañez, P. A., Acebedo, S. L., Cabrera, G. M., Otero, M., Barquero Andrea, Ramírez, J. A. ChemMedChem 2021, 16(12), 1945-1955.

“Tracing Molecular Properties Throughout Evolution: A Chemoinformatic Approach”. Otero, M., Sarno, S., Acebedo, S.L., Ramirez, J. A. Journal of Theoretical Biology 2021, 110601.

“Stochastic population model of Zea mays L.” Barriga Rubio, R.H., Solari, H.G., & Otero, M. Mathematical biosciences 2019, 312, 88-96.

“Multinomial approximation to the Kolmogorov Forward Equation for jump (population) processes”. Natiello, M. A., Barriga, R. H., Otero, M., & Solari, H. G. Cogent Mathematics & Statistics 2018, 5(1), 1556192.

“Comparison of two detailed models of Aedes aegypti population dynamics”. M. Legros, M. Otero, V. Romeo Aznar, H. Solari, F. Gould, A. L. Lloyd. “Ecosphere” 2016, 7(10):e01515. 10.1002/ecs2.1515.

“Modelling dengue epidemic spreading with human mobility”. D. Barmak, C. Dorso, M. Otero. “Physica A” 2016, 447, pp: 129-140. http://dx.doi.org/10.1016/j.physa.2015.12.015

“Effects of Larval Density and Habitat Drying on Developmental Success of Ochlerotatus albifasciatus (Diptera: Culicidae) in Urban Rain Pools: Evidence from Field and Experimental Studies” S. Fischer, V. Sy, R. Campos, M. Otero. “Journal of Medical Entomology”. 2014, 51 (6), pp: 1175-1181. http://dx.doi.org/10.1603/ME14020

“Modelling interventions during a dengue outbreak”. D. Barmak, C. Dorso, M. Otero, H. Solari. “Epidemiology & Infection”. 2014, 142, 545-561. Cambridge University Press. (On-line en Firstview desde 06/2013). DOI: http://dx.doi.org/10.1017/S0950268813001301

“Effects of thermal heterogeneity and egg mortality on differences in the population dynamics of Aedes aegypti (Diptera: Culicidae) over short distances in temperate Argentina”. M. S. De Majo, S. Fischer, M. Otero y N. Schweigmann. “Journal of Medical Entomology” 2013, 50 (3), 543-551. DOI: http://dx.doi.org/10.1603/ME12211

“A mathematically assisted reconstruction of the initial focus of the yellow fever outbreak in Buenos Aires (1871)”. M. L: Fernández, M. Otero, N. Schweigmann y H. Solari. “Papers in Physics” 2013, 5, 050002, 1-25. DOI: http://dx.doi.org/10.4279/PIP.050002

“Modeling the complex hatching and development of Aedes aegypti in temperate climates”. V. Romeo Aznar, M. Otero, M. S. De Majo, S. Fischer y H. Solari. “Ecological Modelling” 2013, 253, pp: 44-55. Elsevier, Amsterdam, Países Bajos. DOI: http://dx.doi.org/10.1016/j.ecolmodel.2012.12.004

“Modeling Dengue Outbreaks”. M. Otero, D. Barmak, C. Dorso, H. Solari y M. Natiello. “Mathematical Biosciences” 2011, 232, 87-95. Elsevier, Amsterdam, Países Bajos. http://dx.doi.org/10.1016/j.mbs.2011.04.006

“Dengue Epidemics and Human mobility”. D. Barmak, C. Dorso, M. Otero, H. Solari. “Physical Review E” 2011, 84, 011901, 1-11. American Physical Society. http://dx.doi.org/10.1103/PhysRevE.84.011901

“Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito”. M. Otero, H. G. Solari. “Mathematical Biosciences” 2010, 223 (1), 32-46. Disponible online desde el 19/10/2009.

“A stochastic spatial dynamical model for Aedes aegypti” M. Otero, N. Schweigmann y H. G. Solari. “Bulletin of Mathematical Biology” 2008, 70 (5), pp: 1297-1325. Springer Verlag. Berlin, Heidelberg.

"A stochastic population dynamics model for Aedes aegypti: formulation and application to a city with temperate climate" M. Otero, H. G. Solari and N. Schweigmann. “Bulletin of Mathematical Biology” 2006, 68 (8), pp: 1945-1974. Springer Verlag. Berlin, Heidelberg.

“Viscoelastic Characterization of Electrochemically Prepared Conducting Polymer Films by Impedance Analysis at Quartz Crystal. Study of the Surface Roughness Effect on the Effective Values of the Thickness and Viscoelastic Properties of the Coating”. A. Arnau, Y. Jiménez, R. Fernández, R. Torres, M. Otero and E. J. Calvo”. “Journal of The Electrochemical Society” 2006, 153 (7), pp: 455-466.

"Characterisation of self-assembled redox polymer and antibody molecules on thiolated gold electrodes" E. Calvo. C. Danilowicz, C. Lagier, J. Manrique, M. Otero. “Biosensors and Bioelectronics” 2004, 19 (10), pp: 1219-1228. Elsevier Science Ltd. The Netherlands.

"Study of atmospheric particulate matter in Buenos Aires city", H. Bogo, M. Otero, P. Castro, M. J. Ozafrán, A. Kreiner, E. J. Calvo, R. M. Negri. “Atmospheric Environment” 2003, 37 (8), pp: 1135-1147. Elsevier Science Ltd. The Netherlands.

"Gravimetric and viscoelastic changes during the oxidation-reduction of layer-by-layer self-assembled enzyme multilayers wired by an Os-containing poly(allylamine) polymer", E. J. Calvo, E. Forzani, M.Otero. “Journal of Electroanalytical Chemistry” 2002 538-539C, pp: 231-241. Elsevier Science Ltd. The Netherlands.

"The structure of layer-by-layer self-assembled glucose oxidase and Os(bpy)2ClPyCH2NH-poly(allylamine) multilayers: ellipsometric and quartz crystal microbalance studies" E. Forzani, M. Otero, M. L. Teijelo, E. Calvo. “Langmuir” 2002, 18 (10), pp: 4020-4029. American Chemical Society, Columbus, OH, USA.

"Study of layer-by-layer self-assembled viscoelastic films on Thickness shear-mode resonator surfaces". E. Calvo, E. Forzani, M. Otero. “Analytical Chemistry” 2002, 74 (14), pp: 3281 - 3289. American Chemical Society, Columbus, OH, USA.

"Layer-by-layer electrostatic deposition of biomolecules on surface for molecular recognition, redox mediation and signal generation". E. Calvo, F. Battaglini, C. Danilowicz, A. Wolosiuk, M. Otero. “Faraday Discussion” 2000, 116, pp: 47–65. Royal Society of Chemistry, Cambridge, UK.

"An EQCM electroacoustic study of poly(vinylferrocene) modified electrodes in different aqueous electrolytes". C. Barbero, E. Calvo, R. Etchenique, G. Morales and M. Otero. Special issue of Electrochimica Acta " The QCM in Electrochemistry", “Electrochimica Acta“ 2000, 45 (22), pp: 3895 - 3906. Elsevier Science Ltd. The Netherlands.

PROCEEDINGS

"Systematic Error Analysis in the determination of physical parameters of the coating in AT Quartz Crystal Resonators Sensors". Y. Jiménez, T. Sogorb, A. Arnau, M. Otero y E. J. Calvo. 4th Acoustic Wave Sensor Workshop 2003. pp: 51-55. Domaine de Valaudran, Salbris, Francia. 23 - 26 Abril de 2003.

"Circuit for continuous motional series resonant frequency and motional resistance monitoring of quartz crystal resonators by parallel capacitance compensation" A. Arnau, T. Sogorb, Y. Jiménez, E. Calvo, M. Otero. Forum Acusticum Sevilla 2002, Sevilla, España, 17 al 20 de septiembre de 2002. http://webistem.com/acoustics2008/acoustics2008/cd1/data/fa2002-sevilla/forumacusticum/archivos/ult04015.pdf

"Wiring efficiency in layer-by-layer (PAA-Os)n(GOx)n self-assembled glucose biosensors". E. J. Calvo, C. Danilowicz, A. Wolosiuk, M. Otero, E. Forzani, M. Lopez Teijelo. “Electrochemical Society Proceedings” 2001, 18, pp: 339 -347. Joint International Meeting of ISE and The Electrochemical Society. San Francisco, USA. 2 - 7 Septiembre de 2001.

CAPÍTULOS EN LIBROS / BOOK CHAPTERS

"QCM Data Analysis and Interpretation" Y. Jiménez, M. Otero, A. Arnau. Chapter XIV in "Piezoelectric transducers and applications" 2nd Edition, pp: 331-398. Antonio Arnau (Editor). Springer Verlag Berlin Heidelberg 2008. ISBN: 978-3-540-77507-2. http://dx.doi.org/10.1007/978-3-540-77508-9_14

"Chemical Sensors" E. J. Calvo, M. Otero. Chapter IX in "Piezoelectric transducers and applications" 2nd Edition, pp: 241-257. Antonio Arnau (Editor). Springer Verlag Berlin Heidelberg 2008. ISBN: 978-3-540-77507-2. http://dx.doi.org/10.1007/978-3-540-77508-9_9

"Data Analysis and Interpretation in Bulk Acoustic Wave - Thickness Shear Mode Sensors" Y. Jiménez, M. Otero, A. Arnau. Chapter XVI in "Piezoelectric transducers and applications", pp: 255 – 286. Antonio Arnau (Editor). Springer Verlag Berlin Heidelberg 2004. ISBN: 3-540-20998-0. http://dx.doi.org/10.1007/978-3-662-05361-4_16

"Chemically Modified Electrodes with Integrated Biomolecules and Molecular Wires". E. J. Calvo, C. Danilowicz, E. Forzani, A. Wolosiuk, M. Otero. Comprehensive Analytical Chemistry. Volume 39: "Integrated Analytical Systems", Chapter VII, pp: 327 – 376. Salvador Alegrett (Editor), Elsevier, 2003. ISBN: 0-444-51037-0. http://dx.doi.org/10.1016/S0166-526X(03)80112-5

"Layered Protein Films: Quartz Crystal Resonator Frequency and Admittance Analysis" E. Calvo, C. Danilowicz, E. Forzani, A. Wolosiuk, M. Otero. Chapter VII in "Biomolecular films: Design, function and applications", pp: 337 - 380. Volumen 111, Surfactant Science Series. J. Rusling (Editor) Marcel Dekker, Inc. 2003. ISBN: 0-8247-0899-7.